John Cusack (Jackson Curtis), Amanda Peet (Kate Curtis), Chiwetel Ejiofor (Adrian Helmsley), Danny Glover (US-Präsident Thomas Wilson), Woody Harrelson (Charlie Frost), Liam James (Noah Curtis), Morgan Lily (Lilly Curtis), Thomas McCarthy (Gordon Silberman), Oliver Platt (Carl Anheuser), Thandie Newton (Laura Wilson), Beatrice Rosen (Tamara), Blu Mankuma (Harry Helmsley), Chang Tseng (Großvater Sonam), Lisa Lu (Großmutter Sonam), Chin Han (Lin Pang), Henry O (Lama Rinpoche), John Billingsley (Professor West), George Segal (Tony Delgatto), Johann Urb (Sasha), Jimi Mistry (Dr. Satnam Tsurutani), Patrick Bauchau (Roland Picard), Stephen McHattie (Captain Michaels), Zlatko Buric (Yuri Karpov), Osric Chau (Nima), Michael Buffer (Ringsprecher), Merrilyn Gann (Deutsche Bundeskanzlerin), Philippe Haussmann (Oleg), Alexandre Haussmann (Alec)