James Stewart (Paul Biegler), Lee Remick (Laura Manion), Ben Gazzara (Lieutenant Frederick Manion), George C. Scott (General Claude Dancer), Arthur O' Connell (Parnell Emmett McCarthy), Eve Arden (Maida Rutledge), Kathryn Grant (Mary Pilant), Orson Bean (Dr. Matthew Smith), John Qualen (Deputy Sheriff Sulo), Murray Hamilton (Alphonse Paquette), Jimmy Conlin (Clarence Madigan), Ken Lynch (Detective Sergeant James Durgo), Alexander Campbell (Dr. W. Gregory Harcourt), Russ Brown (George Lemon), Howard McNear (Dr. Dompierre), Brooks West (Staatsanwalt Mitch Lodwick), Joseph N. Welch (Richter Weaver), James Waters (Sergeant), Royal Beal (Sheriff Battisfore), Duke Ellington (Pie Eye), Joseph Kearns (Lloyd Burke), Don Ross (Duane 'Duke' Miller), Ned Wever (Dr. Raschid)