Harrison Ford (Dr. Richard Kimble), Tommy Lee Jones (Chief Deputy Marshal Samuel Gerard), Sela Ward (Helen Kimble), Julianne Moore (Dr. Anne Eastman), Andreas Katsulas (Frederick Sykes), Jeroen Krabbé (Dr. Charles Nichols), Joe Pantoliano (Cosmo Renfro), L Scott Caldwell (Poole), Olga Zuiderhoek (Dr. Charles Nichols), Ron Dean (Inspector Kelly), Daniel Roebuck (Robert Biggs), Joseph F. Kosala (Detective Rosetti), L. Scott Caldwell (Marshal Poole), Tom Wood (Noah Newman), John Drummond (Nachrichtensprecher), Miguel Nino (Polizist in Chicago), Tony Fosco (Polizist in Chicago), Mark D. Espinoza (Anwohner), Joseph F. Fisher (Otto Sloan), James Liautaud (Paul), Joe Guzaldo (Staatsanwalt), David Darlow (Dr. Lentz), Tom Galouzis (Chirurg), James F. McKinsey (Chirurg), John E. Ellis (Anästhesist), Gene Barge (Polizist im 11. Distrikt), Thomas Charles Simmons (Polizist im 11. Distrikt), Thom Vernon (Carlson), Ken Moreno (Partida), Orlando García (Desmondo), Bruce L. Gewertz (Dr. Bruce)