Jason Schwartzman (Jonathan Ames), Zach Galifianakis (Ray Hueston), Ted Danson (George Christopher), Heather Burns (Leah), Olympia Dukakis (Belinda), Laila Robins (Priscilla), Jessica Hecht (Dr. Donna Kenwood), Kate Micucci (Sherri), Nikki E. Walker (Nurse), Anthony J. Gallo (Dog-Man), Allyce Beasley (Florence Ames), Oliver Platt (Richard Antrem), Olivia Thirlby (Suzanne), Kristen Wiig (Jennifer), Sandrine Holt (Suki)