Morgan Freeman (Dr. Alex Cross), Ashley Judd (Dr. Kate McTiernan), Cary Elwes (Detective Nick Ruskin), Alex McArthur (Detective Davey Sikes), Tony Goldwyn (Dr. William 'Will' Rudolph), Jay O. Sanders (FBI-Agent Kyle Craig), Richard T. Jones (Seth Samuel), Bill Nunn (Detective John Sampson), Brian Cox (Chief Hatfield), Roma Maffia (Dr. Ruocco), Jeremy Piven (), Gina Ravera (), William Converse Roberts (), Helen Martin (), Tatyana Ali (), Mena Suvari (), Heidi Schanz (), Rick Warner (), Billy Blanks (), Dianna Miranda (), Mary Major (), Melinda Renna (), Angel Harper (), Alan Wilder (), Dan Cashman (), Patrick Thomas O'Brien (), Brenda Kincaid (), Lonnie McCullough (), Larry Cedar (), Tresha Rodriguez (), Caroline Case (), Loanne Bishop (), Tim Ahern (), W. Earl Brown (), Brian Brophy (), Michael Cutt (), Meta Golding (), Sadie Stratton (), Brandi Andres (), Dana Seltzer ()