John Wayne (Tom Doniphon), James Stewart (Ransom Stoddard), Vera Miles (Hallie Stoddard), Lee Marvin (Liberty Valance), Edmond O'Brien (Dutton Peabody), Andy Devine (Marshal Link Appleyard), Lee van Cleef (Reese), Ken Murray (Doc Willoughby), John Carradine (Maj. Cassius Starbuckle), Jeanette Nolan (Nora Ericson), Strother Martin (Floyd), Woody Strode (Pompey), Willis Bouchey (Jason Tully), John Qualen (Peter Ericson), Robert F. Simon (Handy Strong), Denver Pyle (Amos Carruthers), Paul Birch (Mayor Winder), Carleton Young (Maxwell Scott), Danny Borzage (Kaintuck), O.Z. Whitehead (Herbert Carruthers), Joseph Hoover (Charlie Hasbrouck)