Bill Murray (Steve Zissou), Owen Wilson (Ned Plimpton), Cate Blanchett (Jane Winslett-Richardson), Anjelica Huston (Eleanor Zissou), Willem Dafoe (Klaus Daimler), Jeff Goldblum (Alistair Hennessey), Michael Gambon (Oseary Drakoulias), Bud Cort (Bill Ubell), Noah Taylor (Vladimir Wolodarsky), Seu Jorge (Pelé dos Santos), Seymour Cassel (Esteban du Plantier), Robyn Cohen (Anne-Marie Sakowitz), Matthew Gray Gubler (Praktikant #1), Niels Koizumi (Bobby Ogata), Pawel Wdowczak (Renzo Pietro), Waris Ahluwalia (Vikram Ray), Antonio Monda (Festival-Direktor), James Hamilton (Festival-Fotograf), Melanie Gerren (Mandeeza), Pietro Ragusa (Akademiker), Noah Baumbach (Phillip), Isabella Blow (Antonia Cook)