Jack Nicholson (Randle Patrick McMurphy), Louise Fletcher (Mildred Ratched), William Redfield (Harding), Will Sampson ('Häuptling' Chief Bromden), Brad Dourif (Billy Bibbit), Peter Brocco ('General' Matterson), Sydney Lassick (Charly Cheswick), Philip Roth (Woolsey), Christopher Lloyd (Taber), Vincent Schiavelli (Fredrickson), Danny DeVito (Martini), Scatman Crothers (Turkle), Nathan George (Washington), Michael Berryman (Ellis), Dean R. Brooks (Dr. Spivey), Alonzo Brown (Miller), Lan Fendors (Schwester Itsu), Louisa Moritz (Rose), Mwako Cumbuka (Warren), Josip Elic (Bancini), Ted Markland (Hap Arlich), William Duell (Sefelt), Ken Kenny (Beans Garfield), Delos V. Smith jr. (Scanlon), Dwight Marfield (Ellsworth), Mews Small (Candy)