Will Smith (Dr. Bennet Omalu), Gugu Mbatha-Raw (Prema Mutiso), Albert Brooks (Dr. Cyril Wecht), Bitsie Tulloch (Keana Strzelczyk), Alec Baldwin (Dr. Julian Bailes), Stephen Moyer (Dr. Ron Hamilton), Arliss Howard (Dr. Joseph Maroon), David Morse (Mike Webster), Matthew Willig (Justin Strzelczyk), Richard T. Jones (Andre Waters), Adewale Akinnuoye-Agbaje (Dave Duerson), Mike O'Malley (Daniel Sullivan), Eddie Marsan (Dr. Steven DeKosky), Luke Wilson (Roger Goodell), Hill Harper (Christopher Jones), Paul Reiser (Dr. Elliot Pellman), Jason Davis (Mr. Scarborough), Gary Grubbs (FBI-Agent), Dan Ziskie (Paul Tagliabue), Britanni Johnson (Rachel Green), Sara Lindsey (Gracie), Alison Moir (Colleen Bailes), Brittney A. Thomas (Altardiener), Samara Lee (Strzelczyks Tochter), Carmen Gangale (Ärztin)