Sally Field (Doris), Max Greenfield (John), Beth Behrs (Brooklyn), Wendi McLendon-Covey (Cynthia), Stephen Root (Todd), Elizabeth Reaser (Doctor Edwards), Tyne Daly (Roz), Natasha Lyonne (Sally), Edmund Lupinski (Priest), Norma Michaels (Doris' Mother), Kumail Nanjiani (Nasir), Rebecca Wisocky (Anne), Rich Sommer (Robert), Leilani Smith (Jogger - Dayplayer), Peter Gallagher (Willy Williams), Susan Ziegler (Prim Organizer), Caroline Aaron (Val), Kyle Mooney (Niles), Isabella Acres (Vivian), Curran Connor (Record Store Clerk), Amy Okuda (Des), Don Stark (Uncle Frank), Nnamdi Asomugha (Shaka), Anna Akana (Blog Girl), Emilie Germain (Stevie), Jack Antonoff (Baby Goya), Sofia Hasmik (Ines), Rayman Jilani (Office Cubicle Worker), Catherine Kresge (Fiona), A.J. Ackleson (Hipster Turkey Man), Lee Chen (Nurse #1), Kale Clauson (Pink Guy), Kate Comer (Hipster Girl), Bren Coombs (Hipster), Sharon Fredrickson (Willow), Tatiana Golykh (Office worker), Nick Hentsch (Record Store Patron), Abraham Lim (Kris), Renna Nightingale (Indie Girl), Eric Pumphrey (Indie Guy), Brenna Rhea (Punk Girl), Roz Ryan (Nurse 2), Guilherme Scarabelot (Keith), Shondale Seymour (Book Seller), Michael Terra (Sawyer)