Morgan Freeman (Dr. Alex Cross), Monica Potter (Jezzie Flannigan), Michael Wincott (Gary Soneji), Dylan Baker (Ollie McArthur), Mika Boorem (Megan Rose), Anton Yelchin (Dimitri Starodubov), Kim Hawthorne (Agent Hickley), Jay O. Sanders (Kyle Craig), Billy Burke (Ben Devine), Michael Moriarty (Senator Hank Rose), Anna Maria Horsford (Vickie), Aaron Joseph (Kennedy), Campbell Lane (Mathias), Christopher Shyer (Jim), Ian Marsh (Sam), Jill Teed (Tracie), Ocean Hellman (Amy Masterson), Penelope Ann Miller (Elizabeth Rose), Ravil Isyanov (Lermontov), Raoul Ganeev (Bodyguard), Samantha Ferris (Mrs. Hume), Scott Heindl (Floyd), Tom McBeath (Chief Cabell), Charles Andre (diplomatischer Polizist), Ronin Wong (Mediziner), Mila Dobrozdravich (Hannah), Brian Arnold (Reporter), Chris Robson (Reporter), Jonathan Walker (Reporter), Suzette Meyers (Reporterin), Tamara Taggart (Reporterin), Debra Donohue (Reporterin), Claire Riley (Nachrichtensprecherin), Donna Lysell (Nachrichtensprecherin), Kevin Hayes (Nachrichtensprecher), Paul Carson (Nachrichtensprecher)