Daniel Craig (James Bond), Ana de Armas (Paloma), Rami Malek (Lyutsifer Safin), Léa Seydoux (Madeleine), Ralph Fiennes (M), Christoph Waltz (Blofeld), Naomie Harris (Moneypenny), Billy Magnussen (Logan Ash), Ben Whishaw (Q), Rory Kinnear (Tanner), Lashana Lynch (Nomi), Jeffrey Wright (Felix Leiter), David Dencik (Valdo Obruchev), Dali Benssalah (Primo (Cyclops)), Lisa-Dorah Sonnet (Mathilde), Coline Defaud (junge Madeleine), Mathilde Bourbin (Madeleines Mutter), Hugh Dennis (Dr. Hardy)