Keanu Reeves (John Wick), Riccardo Scamarcio (Santino D'Antonio), Claudia Gerini (Gianna D'Antonio), Laurence Fishburne (Bowery King), Franco Nero (Julius), Peter Stormare (Abram), Ruby Rose (Ares), Ian McShane (Winston), Bridget Moynahan (Helen Wick), Common (Cassian), Lance Reddick (Charon), John Leguizamo (Aurelio), Thomas Sadoski (Jimmy), Tobias Segal (Earl), Erik Frandsen (Numismatic), David Patrick Kelly (Charlie), Perry Yung (Doctor), Youma Diakite (Lucia), Peter Serafinowicz (Sommelier), Luca Mosca (Italienischer Schneider), Midori Nakamura (Näherin), Mario Donatone (Kardinal), Giorgio Carminati (Priester), Elli (Pfandleiher), Thaddeus Daniels (Nigerianer), Margaret Daly (Operator), Christine Hollingsworth (Barkeeper), Ciscandra Nostalghia (Konzert-Sängerin), Chukwudi Iwuji (Akoni), Vadim Kroll (Cheslav), Simone Spinazze (Kartograph), Chris LaPanta (Earls Bodyguard), Guyviaud Joseph (Earls Bodyguard)