James Marsden (Tom Wachowski), Jim Carrey (Ivo Robotnik / Gerald Robotnik), Tika Sumpter (Maddie Wachowski), Lee Majdoub (Agent Stone), Krysten Ritter (Director Rockwell), Natasha Rothwell (Rachel), Shemar Moore (Randall Handel), Adam Pally (Wade Whipple), Alyla Browne (Maria), Tom Butler (Commander Walters), Ben Schwartz (Sonic), Keanu Reeves (Shadow), Idris Elba (Knuckles), Colleen O'Shaughnessey (Tails), Jorma Taccone (Kyle Lancebottom), Sofia Pernas (Gabriella), Cristo Fernández (Pablo), James Wolk (Young Walters)