Dominic West (Officer James 'Jimmy' McNulty), Chris Bauer (Frank Sobotka), Paul Ben Victor (Spiros 'Vondas' Vondopoulos), John Doman (Colonel William A. Rawls), Idris Elba (Stringer Bell), Lawrence Gilliard Jr. (D'Angelo Barksdale), Wood Harris (Avon Barksdale), Deirdre Lovejoy (A.S.A. Rhonda Pearlman), Clarke Peters (Detective Lester Freamon), Wendell Pierce (Detective William 'Bunk' Moreland)