Sophie Turner (Jean Grey / Phoenix), Jennifer Lawrence (Raven / Mystique), James McAvoy (Professor Charles Xavier), Michael Fassbender (Erik Lehnsherr / Magneto), Jessica Chastain (Vuk), Nicholas Hoult (Hank McCoy / Beast), Evan Peters (Peter Maximoff / Quicksilver), Ato Essandoh (Jones), Tye Sheridan (Scott Summers / Cyclops), Alexandra Shipp (Ororo Munroe / Storm), Kodi Smit-McPhee (Kurt Wagner/ Nightcrawler), Lamar Johnson (Ben Hammil / Match), Kota Eberhardt (Selene Gallio), Scott Shepherd (Dr. John Grey), Summer Fontana (junge Jean Grey), Halston Sage (Alison Blaire / Dazzler), Brian d'Arcy James (US-Präsident), Hannah Anderson (Elaine Grey), Andrew Stehlin (Ariki), Chris Claremont (Gast im Weißen Haus)